Lead white affects the nervous, reproductive, cardiovascular, and immune systems. It can also make people act crazy. In 1862, when James Abbott McNeill Whistler was working on his Symphony in White, No. 1: The White Girl, above, his friends noticed he was acting strange.
At the time, most portraits featured a bright figure against a dark background. But Whistler limited his palette so he could experiment with tonal variation. As a result, he spent a lot of time working with lead white, which wasn’t good for the artist’s body or mind. It was a relief for all in his life when he finally finished the painting.